Mortimer Brewster is happy: he has a job at a New York newspaper, he’s engaged, and he gets to visit his sweet aunts to announce the engagement. Mortimer knew that his family had a bit of a mad gene -his brother believes himself to be Teddy Roosevelt — but his world is turned upside down when he realizes that his aunts have been poisoning lonely men for years!

When Mortimer’s maniacal brother, Jonathan, returns on the night that the aunts were planning to bury the newest victim, Mortimer must rally to help his aunts and protect his fiancé – all while trying to keep his own sanity.